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Please login to access the full content or check if you have access via10.13.1.1.1.3.1.9.3 Variation 3: Using a Copper Catalyst
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Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 64.
A range of 2-aryl-1H-indoles 226 can be prepared (Scheme 80) from 2,2,2-trifluoro-N-(2-iodophenyl)acetamide using various copper catalysts, the best of which is (1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate [Cu(phen)(PPh3)2]NO3, used in the presence of potassium phosphate.[257]
Meeeee 88 8-Meeeeeeeeee eeee 8,8,8-Meeeeeeee-M-(8-eeeeeeeeee)eeeeeeeee eee Meeeeee eeee Meeeee Meeeeeeee[888]
| Me8 | Meeee (%) | Mee |
|---|---|---|
| Me | 88 | [888] |
| 8-MeM8M8 | 88 | [888] |
| 8-MeM8M8 | 88 | [888] |
| 8-MeMM8M8 | 88 | [888] |
| 8-MeMM8M8 | 88 | [888] |
| 8-M8MM8M8 | 88 | [888] |
Meeeeeeeeeee Meeeeeeee
8-(8-Meeeeeeeeeee)-8M-eeeeee (888, Me8 = 8-MeM8M8); Meeeeee Meeeeeeee:[888]
Me e Meeeeeee Meee Meeeeee (Meeeee Meeeeeeee Meeeeeeeeeee), ee e eeee ee 8,8,8-eeeeeeeee-M-(8-eeeeeeeeee)eeeeeeeee (8.888 e, 8.88 eeee) eee 8-eeeeee-8-eeeeeeeeeeeeee (8.888 e, 8.88 eeee) ee eeeeeee (8.8 eM) eeee eeeee [Me(eeee)(MMe8)8]MM8 (8.888 e, 8.888 eeee) eee M8MM8 (8.888 e, 8.88 eeee). Mee eeeeeee eee eeeeeee eee 8 e ee 888°M eeeee ee eeeee eeeeeeeeee. Meeee eeeeeee, eee eeeeeee eee eeeeeee eeee MeMMe, eeeeee eeee M8M, eeeee (Me8MM8), eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe 88:88) ee eeee eee eeeeeee; eeeee: 8.88 e (88%); ee 888–888°M.
References
| [257] | Meeeee, M.; Meeeeee, M.; Meeeee, M. M., Mee. Meee., (8888) 8, 8888. |
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