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Please login to access the full content or check if you have access via Variation 5: From 2-(o-Amidoaryl)enol Ethers and 2-(o-Nitroaryl)enol Ethers

DOI: 10.1055/sos-SD-110-00001

Joule, J. A.Science of Synthesis Knowledge Updates, (20102106.

The introduction of a 2-ethoxyalk-1-enyl substituent as in 423, in which the future α-carbon is a vinyl ether, can be achieved using Suzuki coupling (Scheme 141) of N-acetyl-o-bromoarylamines or o-iodoarylamines 421 with vinylboronate 422. Treatment of enol ether 423 with acid leads to the 1-acetyl-1H-indole 424.[‌363‌,‌364‌]

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