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10.22.3.1.1.2.1.1 From Lithiated ortho-Methylpyridinamines

DOI: 10.1055/sos-SD-110-00972

Mérour, J.-Y.; Joseph, B.Science of Synthesis Knowledge Updates, (20171258.

This method has been used to prepare 1,3-dihydro-2H-pyrrolo[2,3-c]- and 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones.

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Meeeee 8 Meeeeeeee ee 8-Meeeeeeeeee 8-(Meeeeeeeeeeeee)-8,8-eeeeeee-8M-eeeeeee[8,8-e]eeeeeee-8-eeee[‌8‌]

Meeeeeeeeeee ee M,8-eeeeeeeeeeeeeee-8-eeeee (8) eeeeee eee eeeeeeeee ee 8-eeeeee-8,8-eeeeeee-8M-eeeeeee[8,8-e]eeeeeee-8-eee (88) eee eeeeeeee eeee eeeeee eeeeeee (Meeeee 8).[‌8‌]

Meeeee 8 Meeeeeeee ee 8-Meeeee-8,8-eeeeeee-8M-eeeeeee[8,8-e]eeeeeee-8-eee[‌8‌]

Meeeeeeeeeee Meeeeeeee

8-(8-Meeeeeeeeeee)-8-(eeeeeeeeeeeeee)-8,8-eeeeeee-8M-eeeeeee[8,8-e]eeeeeee-8-eee (8, M8 = 8-MeM8M8; M8 = Me); Meeeeee Meeeeeeee:[‌8‌]

Me M-(8-eeeeeeeeeeee)-8-[(eeeeeeeeeeeeee)eeeeee]eeeeeee-8-eeeee (8, M8 = 8-MeM8M8; M8 = Me; 8.88 eee) eeeeeeeee ee eeeee MMM (888 eM) ee −88 °M eeeee M8 eee eeeee e 8.8 M eeee ee MeMe ee eeeeee (88 eM, 8.88 eee). Mee eeeeeee eee eeeeeee ee −88 °M eee 8 e, eeeeee ee −88 °M eee 88 eee, eee eeee eeeeeeee ee −88 °M. Mee eeeeeee eeee eee eeeeee eeee e eeeeeeeeee ee eeeeeeee eee eee (888 eM) ee Me8M (8 M) eeee eeeeeeee. Meeeeeeeeee ee eee eeeeeee eeee e eeeee, eeeee eee eeeeeeeee ee M8M eee eee eeee eee eeeeee eeee Me8M. Mee eeeeeee eeee eee eeeeeeeee ee eM 8 eeee eeeee MMe eee eeeeeeeee eeee MM8Me8. Mee eeeeeee eeee eee eeeee eee eeeeeeee. Meeeeeeeeee ee eee eeeeeee eeeeeee ee eee, eeeee eee eeeeeeeee ee MM8Me8 (888 eM) eee MMM eee eeeee (88 eM). Mee eeeeeee eee eeeeeee ee ee eee 88 e. Mee eeeeeee eee eeeeeee ee eeeeeeeeeee ee eeeee ee eee. Mee eeeeeee eee eeeeeeeeeee eeeeeee ee MeMMM8 eee MM8Me8. Mee eeeeeee eeee eee eeeeeeeee eeee eeeeeeeeee MM8Me8. Mee eeeeeeee eeeeeee eeeee eeee eeeee eee eeeeeeee. Meeeeeeeeee ee eee eeeeeee eeeeeeee eee eeeee eeeeeee, eeeee eee eeeeeeee ee eeeeeeeeeeeeeeeee (eMe8M/eeeeeeeee eeeee); eeeee: 88%.

8-Meeeee-8,8-eeeeeee-8M-eeeeeee[8,8-e]eeeeeee-8-eee (88); Meeeeee Meeeeeeee:[‌8‌]

MMMMMMM: Meeeeeeeeeeeeeeeeeee eeeeeeee ee e eeeeeeee eeeee eeeeeeeeee eee ee eee eee eeee eeeeeeee.

MMMMMMM: Meeeeeeee ee eeee-eeeeeeeeeeee eeeee eeeeeeeeeee eeee eeeee eee eee eeeeee ee eeeee eee.

M eeee ee M,8-eeeeeeeeeeeeeee-8-eeeee (8; 8.88 e, 8.8 eeee) ee MMM (88 eM) eee MMMM (8.88 eM) eee eeeeee ee −88 °M eee e 8.8 M eeee ee e-MeMe ee eeeeeee (8 eM, 8.8 eeee) eee eeeee. Mee eeeeee eeeeeeeeee eee eeeeeee eee 8 e eee eeee e eeeeee ee eee MM8 eee eeeeee ee eee 88 eee. Mee eeeeeee eee eeeeeee eee 8 e ee ee. 8 M ee MMe (8 eM) eee eeeee. Mee eeeeeee eeeee eee eeeeeeee eeee eee. ee Me8MM8, eeeeeee eeeeeeeee eeee Me8M (88 eM) ee eeeeeee e eeeee eeeeee ee eeeeeeee eeeeeeee, eee eeee eeee MMMe8 (88 eM). Mee eeeeee eeeeeee eee eeeee eee eeeeeeeeeeee; eeeee: 8.88 e (88%); ee 888–888 °M (eMe8M).

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