Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
10.23.2.1.1.4.3.4 From 2-(3-Halopyridin-4-yl)anilines

DOI: 10.1055/sos-SD-110-01096

Joule, J. A.Science of Synthesis Knowledge Updates, (20182125.

Only a couple of examples exist in which an amino group displaces a halogen from a 4-(2-aminoaryl)-3-halopyridine, for instance, 2-(3-chloropyridin-4-yl)aniline 376 is transformed into the cyclized product 377 by palladium catalysis with 2-(dicyclohexylphosphino)biphenyl (102) as ligand (Scheme 138),[‌164‌] but there are many more examples in which the nitrogen of an acetamide or sulfonamide serves this purpose (see Sections 10.23.2.1.1.4.3.5 and 10.23.2.1.1.4.3.6).

Meeeee 888 Meeeeeeee-Meeeeeeee Meeeeeeeeeeeee Meeeeeeee eeee ee 8-(8-Meeeeeeeeee-8-ee)eeeeeee[‌888‌]

Me eee eeeeeee eeee ee 8-(8-eeeeeeeeeeeee-8-ee)eeeeeee 888, eeee e eeeeeee eeeeeeeee ee eee eeeee eeeeee eeeee, eee eeeeeee eee ee eeeeeeeee ee eee eeeee eeeee eeeeee ee eeeeeee eeee eeeeeeeeee eeeeeeee ee eeee 888°M eeeeee 8M-eeeeee[8,8-e]eeeeee 888 ee 88% eeeee (Meeeee 888).[‌888‌]

Meeeee 888 Meeeeeeeeeeeee Meeeeeeee eeee e 8-(8-Meeeeeeeeeeee-8-ee)eeeeeee[‌888‌]

Meeeeeeeeeee Meeeeeeee

(M)-8-Meeeee-8-(8-eeeeeeeeeeeeeeee-8-ee)-8M-eeeeee[8,8-e]eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

M eeee ee 8-{8-eeeeee-8-eeeeee-8-[(M)-8-eeeeeeeeeeeeeeee-8-ee]eeeeeee-8-ee}eeeeeee (888; 88ee, 8.888eeee, 8.8eeeee), Me8(eee)8 (8ee, 8 µeee, 8.8eeeee), 8-(eeeeeeeeeeeeeeeeeeeee)eeeeeeee (888; 8ee, 8.888eeee, 8.8eeeee), eee Me8MM8 (88ee, 8.88eeee, 8.8eeeee) ee 8,8-eeeeeee (8eM) eee eeeeeeee eeee eeeee eee 88eee eee eeee eeeeee ee 888°M eee 88e. Mee eeeeeee eee eeeeee ee ee, eeeeee eeee eee. ee MeMMM8, eee eeeeeeeee eeee MM8Me8 (8 × 8eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeee (M8MM8), eeeeeeee eeeeeee Meeeee, eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeeee MMM (eeeeee eee, MeMM/MM8Me8 8:88) ee eeeeee eee eeeeeee ee ee eee-eeeee eeeee; eeeee: 88ee (88%); ee 888888°M.

8-Meeeee-8-(8M-eeeeee[8,8-e]eeeee-8-ee)eeeee-8-eee (888); Meeeeee Meeeeeeee:[‌888‌]

Meeee eee (888°M) eeMMe (88e) eee eeeee ee 8-[8-(8-eeeeeeeeeee)-8-eeeeeeeeeeeee-8-ee]-8-eeeeeeeeeee-8-eee (888; 88ee, 8.88eeee) eee eee eeeeeee eee eeeeee ee 888°M eee 88eee. Mee eeeeeeeee eee eeee eee eeeeee eeee e eeeeeee ee eee eee eeeee MM8. Mee eeeeeee eeeee eee eeeeeeeee eeee MeMMe. Mee eeeeeee eee eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee, eeeeeeeee eee eeeeee eeeeeee; eeeee: 88%; ee 888°M.

References


Cookie-Einstellungen