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10.24.4.1.2.1.1.1.1 Synthesis from Ethyl 1-(2-Oxo-2-phenylethyl)-1H-indole-2-carboxylate

DOI: 10.1055/sos-SD-110-02056

Harris, P. A.Science of Synthesis Knowledge Updates, (20213147.

Ethyl 1-(2-oxo-2-phenylethyl)-1H-indole-2-carboxylate (12), readily prepared by N-alkylation of ethyl 1H-indole-2-carboxylate (11) with phenacyl bromide, undergoes cyclization with ammonium acetate to afford 3-phenylpyrazino[1,2-a]indol-1(2H)-one (13) in good yield (Scheme 3).[‌6‌] Both steps are efficiently carried out via microwave irradiation in a short reaction time. Upon heating, the ammonium acetate decomposes to acetic acid and ammonia to induce the cyclization reaction.

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