Science of Synthesis

Singh, F. V., Science of Synthesis Knowledge Updates, (2021) 1, 143.

General Introduction

This is an update to the original Science of Synthesis chapter from 2003 (Section 14.3) on pyranones and pyranthiones.[‌1‌] The specific ring systems covered within this class of compounds are 2H-pyran-2-ones (Section ‌14.3.5.1‌), 2H-pyran-2-thiones (Section ‌14.3.5.2‌), and 4H-pyran-4-ones (Section ‌14.3.5.3‌) (‌Scheme 1‌). The focus is on reports from the literature that were published between 2000 and 2019; during this time numerous new approaches for preparing and modifying 2H-pyran-2-ones and 4H-pyran-4-ones were disclosed. In contrast, relatively few new methods for the synthesis of 2H-pyran-2-thiones have been reported, and no significant developments for the synthesis of 4H-pyran-4-thione compounds have been reported.

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References