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15.1.4.1.4.1.1.5.1 Nitration of Pyridines

DOI: 10.1055/sos-SD-115-00035

Spitzner, D.Science of Synthesis Knowledge Updates, (20161188.

Direct nitration of pyridines and pyridine analogues with concentrated nitric acid (or potassium nitrate) in trifluoroacetic anhydride, followed by treatment with sodium metabisulfite involves dinitrogen pentoxide (N2O5) and gives the corresponding nitropyridines 364 in 10–83% yield (Scheme 271).[‌558‌]

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