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15.5.4.1 Isoquinolines

DOI: 10.1055/sos-SD-115-00651

Pilgrim, B. S.; Tucker, M. J.Science of Synthesis Knowledge Updates, (20191181.

Isoquinoline is a 10π-electron aromatic heterocycle, which was first isolated from coal tar in 1885. The systematic numbering of isoquinoline is shown in Scheme 1. Although the term isoquinoline formally refers to the fully aromatic system, it has come to be used more loosely when describing more saturated versions of the same framework (such as the di-, tetra-, and decahydroisoquinolines). This update will focus on the fully aromatic system but it will also feature selected examples of the synthesis of more reduced skeletons.

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References


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