Science of Synthesis

von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 117.

Aryl methyl ketones, aromatic aldehydes, aromatic nitriles, and hydroxylamine undergo a one-pot, four-component reaction under solvent-free conditions and microwave irradiation to produce 2,4,6-triarylpyrimidines ‌59‌ (‌Scheme 24‌).[‌69‌] The reported yields are in the range of 86 to 95%. It is assumed that two distinct reactions occur prior to the ring closure: formation of a chalcone and formation of an amidoxime. These and similar components are often used in pyrimidine synthesis (see Section ‌16.12.1.7.4.21‌).

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References