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16.12.1.6.4.7.3 Reaction of Hexacarbonylmolybdenum(0) with Alkynes, Amidines, and Iodobenzene

DOI: 10.1055/sos-SD-116-00063

von Angerer, S.Science of Synthesis Knowledge Updates, (20111146.

In an interesting one-pot, four-component synthesis, arylacetylenes react with amidine derivatives, hexacarbonylmolybdenum(0), and iodobenzene to afford 4-aryl-6-phenylpyrimidines 116 in acceptable yields (Scheme 65).[‌153‌] This reaction proceeds via a 3-aryl-1-­phenylprop-2-yn-1-one intermediate formed by the alkyne, carbon monoxide from hexacarbonylmolybdenum(0), and the phenyl group of iodobenzene. When (substituted) hydrazine is used instead of the amidine, pyrazoles are formed.[‌153‌]

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