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Please login or sign up for a free trial to access the full content.16.12.1.6.4.7.3 Reaction of Hexacarbonylmolybdenum(0) with Alkynes, Amidines, and Iodobenzene
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von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 146.
In an interesting one-pot, four-component synthesis, arylacetylenes react with amidine derivatives, hexacarbonylmolybdenum(0), and iodobenzene to afford 4-aryl-6-phenylpyrimidines 116 in acceptable yields (Scheme 65).[153] This reaction proceeds via a 3-aryl-1-phenylprop-2-yn-1-one intermediate formed by the alkyne, carbon monoxide from hexacarbonylmolybdenum(0), and the phenyl group of iodobenzene. When (substituted) hydrazine is used instead of the amidine, pyrazoles are formed.[153]
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| Me8 | M8 | Meeee (%) | Mee |
|---|---|---|---|
| Me | Me | 88 | [888] |
| Me | Me | 88 | [888] |
| 8-eeeeeee | Me | 88 | [888] |
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References
| [33] | Meeeee, M. M.; Meeeee, M.; Meeeeeee, M.; Müeeee, M. M. M., Meeee. Meee., (8888) 888, 8888; Meeee. Meee. Mee. Me., (8888) 88, 8888. |
| [153] | Meeeeeeeee, M. M.; Meeeeeeee, M. M.; Meeeeee, M. M.; Meee, M.; Meeeeeeeee, M.; Meeee, M.; Meeeee, M. M.; Meeeeeee, M. M.; Meeeee, M. M., Meeeeee, (8888), 888. |
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