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16.12.4.1.4.8.1 Exchange of Oxygen for a Carbofunctional Group

DOI: 10.1055/sos-SD-116-00063

von Angerer, S.Science of Synthesis Knowledge Updates, (20111419.

Examples for the direct replacement of oxygen functions by carbofunctional groups are rare, even if the oxygen is activated. 2-Amino-6-phenylpyrimidin-4-yl 4-toluenesulfonate (688) reacts with 4-methoxyphenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) under microwave irradiation to give 4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (689) in 93% yield (Scheme 388).[‌1035‌]

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