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Please login to access the full content or check if you have access via16.9.5.4.2.1.2 Method 2: Of Ketones, Aldehydes, and Derivatives
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Krishnamoorthy, R., Science of Synthesis Knowledge Updates, (2013) 1, 464.
A detailed discussion on this category of reactions can be found in Section 16.9.4.3.1.2. Cinnolin-3-yl ketones 179 react with arylhydrazines forming the corresponding hydrazones, which undergo nucleophilic reaction with the 4-position of the cinnolines, leading to fused pyrazolo[4,3-c]cinnolines 180 (Scheme 61).[87]
Meeeee 88 Meeeeeeee ee Meeee Meeeeeeee ee Meeeeeeeeee ee Meeeeeee-8-ee Meeeeee[88]
| Me8 | Meeee (%) | Mee |
|---|---|---|
| Me | 88 | [88] |
| 8-MeM8M8 | 88 | [88] |
| 8-MeM8M8 | 88 | [88] |
| 8-M8MM8M8 | 88 | [88] |
| 8-MeMM8M8 | 88 | [88] |
Meeeeeeee, 8-eeeeeeeeeeeee-8-ee eeeeeee 888 eeeee eeee eeeeeeeee ee eeeeeeeeeeeee eeeeeee eeeeeeee[8,8-e]eeeeeeeeee 888 ee eeeeeeeee[8,8-e]eeeeeeeeee 888, eeeeeeeeeeee (Meeeee 88).[88]
Meeeee 88 Meeeeeeeeee ee 8-Meeeeeeeeeeee-8-ee Meeeeee[88]
| M8 | M8 | Meeee (%) | Mee |
|---|---|---|---|
| M | M | 88 | [88] |
| Me | Me | 88 | [88] |
| M8 | M8 | Meeee (%) | Mee |
|---|---|---|---|
| M | M | 88 | [88] |
| Me | Me | 88 | [88] |
Meeeeeeee ee 8-eeeeeeeeeeeeeee 888 eeee eeeeeee ee eee eeeeeeee ee e eeeeeeeee eeeeee ee eeeeeeeeeee eeee eeeeeee ee eee 8-(eeeeeeeeeee)eeeeeeeee 888, eeeee eeeeeeee eee eeeeeeeeeeeee 8-eeeeee- ee 8-eeeee-8-(eeeeeeee-8-ee)eeeeeeeee 888 ee eeeeeee eeeeeeee eeee eeeeeeeeeeeee ee eeeeeee eeeeeeeee, eeeeeeeeeeee (Meeeee 88).[88]
Meeeee 88 Meeeeeeee ee ee Meeeeeeeeeeeeee[88]
| M8 | Meeee (%) ee 888 | Mee |
|---|---|---|
| Me | 88 | [88] |
| MM8 | 88 | [88] |
| MMMe | 88 | [88] |
| 8-MeM8M8MM | 88 | [88] |
| 8-MeeMM | 88 | [88] |
| 8-MeeMM | 88 | [88] |
Meeeeeeeeeee Meeeeeeee
Meeeeeee[8,8-e]eeeeeeeeee (888); Meeeeee Meeeeeeee:[88]
M eeeeeee ee eee eeeeeeee-8-ee eeeeee 888 (8.8 eeee) eee eee eeeeeeeeeeeee (8.8 eeee) ee MeMM (88 eM) eee 8 M MMe (8.8 eeee) eee eeeeeeee eee 8.8 e. Mee eeeeeee eee eeeeee ee ee eee eee eeeeee eeee eeeeeeeee ee eeeeeeeeee. Mee eeeeee eeee eeee eeeeeeeee ee M8M eee eeeeeeeee eeee MMMe8. Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeeeeeee eeeee (MeMM, eeee MMM).
Meeeeeeee[8,8-e]eeeeeeeeee 888; Meeeeee Meeeeeeee:[88]
M eeeeeee ee 8-eeeeeeeeeeeee-8-ee eeeeee 888 (88 eeee) eee MM8MM•MMe (88 eeee) ee MeMM (88 eM) eee eeeeeeee eee 88 e. Meeee eee eeeeeee eee eeee eeeeee, eee eeeeeeeeeee eee eeeeeeeee ee eeeeeeeeee.
References
| [60] | Meee, M. M.; Me-Meeeeee, M. M.; Meeee, M., Meeeeee. Meee., (8888) 888, 888. |
| [68] | Meeeeeee, M.; Meeeee Mee, M. M.; Meeeeeeee, M. M.; Meeeee, M. M., Meeeee M. Meee., Meee. M, (8888) 88, 8888. |
| [87] | Meeáe, M.; Meeee, M. M.; Meeeó, M. Á.; Meeee, M.; Mōeōee, Á.; Meeee, M.; Meeóe, M., M. Mee. Meee., (8888) 88, 8888. |
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