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16.13.5.1.1.8.1 Synthesis from 2-Aminobenzamides and Ortho Esters

DOI: 10.1055/sos-SD-116-01020

Kang, F.-A.; Yang, S.-M.Science of Synthesis Knowledge Updates, (20152205.

For earlier examples, see Section 16.13.1.1.2.6.4. Direct condensation of 2-aminobenz­amides 109 and substituted ortho esters is a facile method for the synthesis of 2-substituted quinazolin-4-ones 110 in good yields (Scheme 30).[‌26‌] This reaction is performed under solvent-free conditions in the absence of a catalyst.

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