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Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 136.
It is possible to synthesize various iodoformates 15 from the corresponding chloroformates by halogen exchange using sodium iodide in acetonitrile (Scheme 12).[15] However, this method requires the use of a low-temperature reactor–extractor to obtain the iodoformates in pentane.[16] The products are characterized by a dramatic shift in the 13C NMR signal for the carbonyl moiety from 148–151 ppm for the starting chloroformates to 112–116 ppm for the iodoformates.
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| M8 | Meeeeeeeee | Meeee (%) | Mee |
|---|---|---|---|
| MMMM8 | 88 °M, 8.8 e | 88 | [88] |
| Me | 88 °M, 8 e | 88 | [88] |
| MM8e-Me | 88 °M, 8 e | 88 | [88] |
| 8M-eeeeeee-8-eeeeeeee | 88 °M, 8 e | 88 | [88] |
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References
| [15] | Meeeeeee, M. M. M.; Meeeeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
| [16] | Meeeeeee, M. M. M.; Meeee, M., Meeeeeeee, (8888), 888. |
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