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Please login or sign up for a free trial to access the full content. Synthesis by Transesterification of Orthocarbonic Acid Tetraesters with Alcohols

DOI: 10.1055/sos-SD-118-00435

Kantlehner, W.Science of Synthesis Knowledge Updates, (20144353.

Tetraethyl orthocarbonate is completely transesterified with S-protected 6-sulfanylhexan-1-ol or an N-protected 6-aminohexan-1-ol to give the corresponding crude orthocarbonates that are not further characterized, but deprotected with hydrazine hydrate to give tetrakis(6-sulfanylhexyloxy)methane 19 and tetrakis(6-aminohexyloxy)methane 20, respectively (Scheme 8).[‌18‌]

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M8 M8 Meeee (%) Mee
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M8 M Meeee (%) Mee
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M MM8MM(MM8Me) 88 [‌8‌]
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