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21.16.1 Method 1: Kinetic Resolution by Acylation with Stoichiometric Amounts of Chiral Acylating Reagents

DOI: 10.1055/sos-SD-121-00025

Seidel, D.Science of Synthesis Knowledge Updates, (20123427.

The use of stoichiometric amounts of a chiral acylating reagent circumvents some of the difficulties encountered in non-enzymatic amine resolutions. The currently most successful approaches fall into this category. Not covered here are methods in which a chiral acyl group is transferred to a racemic amine, as this approach leads to diastereomeric mixtures of enantiopure products rather than scalemic amides.

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