You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via22.1.7.2.1.1.1 With Potassium Carbonate and N,N-Diethylaniline as Activators
Please login to access the full content or check if you have access via
Tang, R.-Y., Science of Synthesis Knowledge Updates, (2024) 1, 336.
Potassium carbonate and a catalytic amount of N,N-diethylaniline can promote the sulfurization of amides with phosphorus pentasulfide. N,N-Diethylaniline may react with phosphorus pentasulfide to form an active thionating agent for sulfurization of amides. The sulfurization of aryl and alkyl amides 1 proceeds well in dichloromethane under reflux conditions, providing primary and secondary thioamides 2 in moderate to high yields (Scheme 2).[5] This method is also applicable to the transformation of esters into thioesters.
Meeeee 8 M,M-Meeeeeeeeeeeee-Meeeeeeeeee Meeeeeeeeeeee ee Meeeee[8]
| M8 | M8 | Meee (e) | Meeee (%) | Mee |
|---|---|---|---|---|
| Me | M | 8 | 88 | [8] |
| Me | Me | 8 | 88 | [8] |
| Me | Me | 8 | 88 | [8] |
| 8-MeMM8M8 | M | 8 | 88 | [8] |
| 8-e-MeM8M8 | M | 8 | 88 | [8] |
| 8-MeM8M8 | M | 8 | 88 | [8] |
| 8-Mee | M | 8 | 88 | [8] |
| Me | Me | 8 | 88 | [8] |
| e-Me | Me | eeeeeeeee | 88 | [8] |
| Me | Me | 8 | >88 | [8] |
Meeeeeeeeeee Meeeeeeee
Meeeeeeeee 8; Meeeeee Meeeeeeee:[8]
M eeeeeee eeeeeee ee M8M88 (8 eeee), M8MM8 (88.8 eeee), ee eeeee 8 (88 eeee), M,M-eeeeeeeeeeeeee (8 eee%), eee MM8Me8 (88 eM) eee eeeeee ee eeeeee eeeeeeeeeee eeeee ee eeeee eeeeeeeeee eee eee eeeeeeeee eeee. Mee eeeeeee eee eeeeee eeeeeeeeeeee eeee 8 M ee MMe eee eeeee, eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee.
References
| [5] | Meee, M.-M.; Me, M.-M.; Meee, M.-M.; Me, M.-M., Meeeeeeeeee, (8888) 88, 888. |
Return to Top