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22.4.9.2.1.2 Silylation of N,N,N′-Trimethylformimidamide

DOI: 10.1055/sos-SD-122-00164

Huang, H.; Deng, G.-J.; Ji, X.Science of Synthesis Knowledge Updatesearly view.

The N-silylated trimethylformimidamide trifluoromethanesulfonate 3 can be obtained in almost quantitative yield by treatment of N,N,N-trimethylformimidamide with trimethylsilyl trifluoromethanesulfonate (Scheme 2).[‌4‌] Further treatment of 3 with the weakly nucleophilic bulky base lithium hexamethyldisilazanide leads to formation of a silylformamidine, which can be considered as a latent nucleophilic carbene.[‌4‌,‌5‌]

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