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Please login to access the full content or check if you have access via22.7.2.2.1.1.2 Conversion of Aliphatic Formates into Difluoromethyl Ethers
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Zhu, H.; Fan, Q., Science of Synthesis Knowledge Updates, (2024) 3, 371.
Difluoromethyl ethers 4 are formed from formates 3 by treatment with phosphorus pentachloride to give dichloromethyl ethers and subsequent chlorine–fluorine exchange (Scheme 2).[5] The chlorine–fluorine exchange is carried out at room temperature by a solvolysis process using triethylamine trihydrofluoride (Et3N•3HF) as the exchange medium, with hydrogen fluoride being the ultimate source of fluorine.
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References
| [5] | Meeeeee, M. M., Me.; Meee, M.; Meee, M.; Meeeeeee, M. M.; Meee, M., M. Meeeeeee Meee., (8888) 888, 88. |
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