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26.8.4.2.1 Method 1: Synthesis from Arenes via C—H Activation

DOI: 10.1055/sos-SD-126-00085

Sellars, J. D.Science of Synthesis Knowledge Updates, (20141412.

As highlighted in Section 26.8.4.1.1, conversion of arenes into aryl ketones can be achieved through Friedel–Crafts chemistry; however, there is an increasing focus on the activation of C—H bonds utilizing metals.[‌70‌] Direct activation of arene C—H bonds is possible, allowing for the formation of aryl ketones (e.g., 15) by reaction with acid chlo­rides[‌71‌,‌72‌] or nitriles (Scheme 21).[‌73‌,‌74‌]

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