Science of Synthesis

Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 441.

Arynes generated from ortho-silylaryl trifluoromethanesulfonates on treatment with cesium fluoride react smoothly with aryl dimethylhydrazones to generate aryl ketones possessing an ortho-dimethylamino group (‌Scheme 64‌).[‌180‌] Interestingly, this methodology is exploited to produce a naturally occurring acridone which, when demethylated, exhibits anti-HIV activity.

‌Meeeee 88‌ Meeeeeee ee e Meeeeeeeeeeeeeeee eeee ee Meeee[‌888‌]

Meeeee eeee eeeee eeee β-eee eeeeee ee eeeeeee eeee eeeeeee. Meee eeeeeeee eee eeee eeeeeee ee e eeeee ee eeeeeeeeeee eeeeee eee β-eee eeeeee (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Meeeeeeee–Meeeeeeeee ee Meeeeeeeeee Meeeee eeee β-Mee Meeeee[‌888‌]

‌Meeeeeeeeee 88‌

e Meeeeee ee eeee- (M8 = Me; M8 = M; M8/M8 = MMM8M) eee eeee-eeeeeeeeeee (M8 = Me; M8/M8 = MMM8M; M8 = M) eeeeeeeeeeee (8.8:8).

Meeeeee, eeee-α-eeeeeeeeeee β-eee eeeeee eee eee eeeeee eeeeeeeeee ee eee eeeeeeeeee eeeeeeee eeeeeeeeee (e.e., ‌88‌) eee eeeeeeee ee eeeeeeeeee eeeeee, eeeeeeeeee eee ee eeeeee eeeeeeee ee eee eeeeeeeeeeeeeeee eeeeeeeeeeee (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Meeeeeeee eee eee Meeeeeeee ee eee Meeeeeeeee Meeeeeee Meeeeeeee[‌888‌]

Meee eeeeeeeeeee eee eeeeeeeeeeee eeee eeeeeeeee eeee eeeeee β-eee eeeeee ee eeeeeee eeee-eeeeeeee eeee eeeeeee ee eeee eeeee (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Meeeeeeee ee Meee Meeeeee eeee Meeeee eee 8,8-Meeeeeeeeee[‌888‌]

Me e eeeeeee eeeeeee, eeeeeeeee eeeee eeee eeeeee ee eeeeeee eeee eeeeeee ee eeeeeeeee eeeee. Mee eeeeeeee ee eeeeeee eeeeeeeeee ee eeeeeeeeeee eeeeee eee eeeeeeeee, eeeeeeeee eeeeee ee e eeeeeee ee eeee eeeeeee (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Meeeeeeee–Meeeeeeeeeeeee ee ee Meeee[‌888‌]

‌Meeeeeeeeee 88‌

References