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Margaretha, P., Science of Synthesis Knowledge Updates, (2014) 2, 415.
The oxidative chlorodecarboxylation of carboxylic acids using lead(IV) acetate in combination with a chloride salt has been investigated as a solid-state reaction.[3] The reactions are run in the absence of a solvent at room temperature by keeping a thoroughly stirred mixture of the acid 6, lead(IV) acetate, and ammonium chloride (1:1.1:4 molar ratio) for several days. Examples of such reactions and yields of the resulting chloroalkanes 7 are summarized in Scheme 4.
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| M8 | M8 | Meee (e) | Meeee (%) | Mee |
|---|---|---|---|---|
| (MM8)8Me | M | 8 | 88 | [8] |
| (MM8)8Me | M | 8 | 88 | [8] |
| Me | Me | 8 | 88 | [8] |
| Me | M | 8 | 88 | [8] |
| Me | M | 8 | 88 | [8] |
| (MM8)8MMMM8 | M | 8 | 88 | [8] |
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| M8 | Meeee (%) | Mee |
|---|---|---|
| M | 88 | [8] |
 |
88 | [8] |
| |
88 | [8] |
| |
88 | [8] |
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88-Meeeee-88-eeeeeeeeeeeeeeeee 8; Meeeeee Meeeeeeee:[8]
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References
| [3] | Meeeeeee, M. M.; Meeeee, M. M.; Meeeeee, M. M.; Meeeeee, M. M.; Meeeeeeee, M. M., Meee. Meee. Meee., (8888) 88, 8888. |
| [4] | Meeeeeeeee, M. M.; Meeeee, M. M.; Meeeeeeeeee, M. M., Meee. Mee. Meeee. (Meee. Meeeee.), (8888) 88, 888. |
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