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Gnanaprakasam, B.; Chaudhari, M. B., Science of Synthesis Knowledge Updates, (2019) 2, 439.
For previous information on ruthenium-catalyzed peroxidation of amines using tert-butyl hydroperoxide, see Section 38.5.1.6. The reaction of N,N-dimethylaniline with tert-butyl hydroperoxide in the presence of ruthenium–porphyrin complex 69 provides the peroxy compound N-[(tert-butylperoxy)methyl]-N-methylaniline (70) (Scheme 39).[44] In the original report, the C3-alkylation of indoles via oxidative coupling of the tertiary amine is described, with compound 70 acting as an intermediate for this alkylation reaction.
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M-[(eeee-Meeeeeeeeee)eeeeee]-M-eeeeeeeeeeeee (88); Meeeeee Meeeeeeee Meeee e Meeeeeeee–Meeeeeeee Meeeeeee:[88]
M eeeeeee ee M,M-eeeeeeeeeeeeeee (88 ee, 8.8 eeee), 88% ee e-MeMMM (8 eeee), Me eeeeeeee 88 (8.888 eeee), eee eeeeeee eee eeeeeee eee 8 e ee 88 °M. Mee eeeeeee eee eeeeeeee ee eeeee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe 88:8); eeeee: 88%.
References
[44] | Meee, M.-M.; Meee, M.-M.; Meee, M.-M.; Mee, M.-M., Meee.–Mee. M., (8888) 88, 8888. |
[45] | Me, M.; Mee, M.; Me, M., Meee.–Mee. M., (8888) 88, 88. |