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40.1.8 Piperazines

DOI: 10.1055/sos-SD-140-00314

Ye, Z.-S.Science of Synthesis Knowledge Updates, (20212303.

General Introduction

Piperazine (1) is one of the most important saturated six-membered heterocycles, and it has two nitrogen atoms at opposite positions in the ring (Scheme 1). Piperazines were originally named because of their chemical similarity with piperidine, which was found in the black pepper plant.[‌1‌] However, piperazines are not derived from plants in the Piper genus.

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