Science of Synthesis

Muñiz, K., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 6.

Ruthenium-based catalysis has long been recognized as a potential alternative to osmium; however, selectivity has been a long-standing problem in this area,[‌12‌] with the major problem experienced being overoxidation resulting in C—C bond cleavage. However, recent important progress has led to the development of nondegradative conditions using ruthenium catalysts.

Meeeeeee eeeeeeee eeeeeeeeee eee eee eeeeeeeeeeeeee ee eeeeeee ‌8‌ eeee eeeee ‌8‌ eeee eeeeeeeee eeeeeeeee ee Meee eeeeee e eeeeeeeeeeeeee eeeeeeeeeeeeee,[‌88‌,‌88‌] eee Meeee, eee eeeeeeee ee eeeeeeeee eeee eeeeeeeeeeeeee eeee ee eeee eeeeee eeeeeeeee(MMMM) eeeee, e eeeeeee eeeee ee eeeeeeeee eeeeeeee ee ee eeeee eeeeeeeeeeeeeee (‌Meeee 8‌).[‌88‌,‌88‌]

‌Meeee 8‌ Meeee Meeeeeeeeeeeeee ee Meeeeee eeee Meeeeeeee(MMMM) Meeee[‌88‌,‌88‌]

Meeeeeee Meeeeeee	Meee (e)	Meeeeee	Meeee (%)	Mee
	888		88	[‌88‌]
	88		88	[‌88‌]
	888		88	[‌88‌]
	888		88	[‌88‌]
	888		88	[‌88‌]

Meeeeeee, Meeeeeee eee eeeeeeeee e eeeeee ee eeeeeeeeee eee eeeeeeeee ee eeeee eee 8,8-eeeeeeeeeeeeeee eeeeeeeee ee eeeeeee ‌8‌ ee eeee eeeee ‌8‌ eeeee eeee eeee eeeeeeeee eeeeeeeeee (‌Meeee 8‌). Me eeeeeeeeee, eee eeeeeeeeeee eeee eeeeee eeeeeeeeee eeeeeeeeeeeee eeeeeee eee eeeeeeeee ee eeeee eee eee ee ee eeeeeeee eeeeeeee eeee eeeeee eee e eeeee eee eeeeeeeeee eeee eeeeeeeee eeeee eeeeeeee eeeeeeeeee.[‌88‌,‌88‌] Me eeee eeeee, eeeeeeee ee eeeeee(MMM) eeeeeeee ee eeeee ee eeee e eeeeeeeeee eeeeee.[‌88‌]

‌Meeee 8‌ Meeeeeeee(MMMM) Meeee Meeeeeeee Meeeeeeeeeeeeee ee Meeeeee[‌88‌,‌88‌]

Meeeeeee Meeeeeee	Meeeeee	Meeeee (%)	Mee
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88	[‌88‌]
		88e	[‌88‌]

e Meeeeeeee eeeeeeeee ee e eeeeeeeeeeeee ee 8.88 M ee eeeeee.

e 88% ee.

Meeeeeeeeeee Meeeeeeee

Meeee ‌8‌; Meeeeee Meeeeeeee:[‌88‌]

Me e 88-eM, eeeee-eeeeeeee eeeee eeeeeeee eeee e eeeeeeee eeeeeee eee eee ee eeeeeeeeeeee eeeee, MeMM8 (888 ee, 8 eeee) eee eeeeeee ee M8M (8.8 eM) eee 8 M M8MM8 (888 µM, 8.8 eeee) eee eeeee. Meeee eee eeeee eee eeeeeeeee, eee eeee eee eeeeee ee 8 °M. M 8.8 M eeeeeee eeee ee MeMe8 (888 µM, 8.88 eeee) eee eeeee eee eee eeeeeee eee eeeeeee eeeee ee eeeeee eeeeee eeeeee. MeMMe (8 eM) eee eeeee eee eeeeeeee eee eeeeeeeee eee e eeeeeee 8 eee. MeMM (8 eM) eee eeeee eee eeeeeeee eee eeeeeeeee eee e eeeeeee 8 eee. Mee eeeeee ‌8‌ (8 eeee) eee eeeee ee eee eeeeeee, eee eee eeeeeeeee eeeeee eee eeeeeee eeeee eee eeeeeeee eeeeeeee eee eeeeeeee. Mee eeeeeee eee eeeeee eeee e eeeeeee ee eee. ee MeMMM8 (88 eM) eee eee. ee Me8M8M8 (88 eM). Mee eeeeee eeee eeeeeeeee eee eee eeeeeee eeeee eee eeeeeeeee eeee MeMMe (8 × 88 eM). Meeee eeeeee (Me8MM8) eee eeeeeeee eeeeeee eeeee eee eeeeeeeeeee ee eee eeeeeee eeeee eeeeeee eeeeeeee, eee eeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee.

References