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1.3.1.1 Three-Phase Conditions

DOI: 10.1055/sos-SD-201-00050

Colonna, S.; Perdicchia, D.Science of Synthesis: Stereoselective Synthesis, (20111125.

The α-poly(amino acid)-catalyzed JuliàColonna epoxidation has emerged as an efficient method for the enantioselective functionalization of α,β-unsaturated ketones. Since its discovery in 1980, the reaction conditions have been continually optimized. The original procedure for epoxidation of electron-deficient alkenes was based on a triphasic system comprising a poly(amino acid), an aqueous phase, and an organic phase.[‌10‌,‌11‌]

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e-Mee (8888) 88 88 8 [‌88‌]
e-β-Me-Mee 888 8 8 [‌88‌]
e-β-Me-Mee 888 88 88 [‌88‌]
(e-Mee-e-Mee)88 88 88 88 [‌88‌]
(e-Mee-e-Mee)88 88 88 88 [‌88‌]
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References


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