Science of Synthesis

Muchalski, H.; Johnston, J. N., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 155.

General Introduction

Aziridines are the smallest carbocycles containing one nitrogen atom. Due to their angle strain, they exhibit a synthetically useful balance between stability and reactivity. Thus, they are often employed as versatile intermediates. The ability of aziridines to undergo highly regio- and stereoselective ring-opening reactions makes them of great value in organic synthesis. The properties, synthesis, and applications of aziridines have been thoroughly reviewed.[‌1‌–‌6‌] Methods for aziridine synthesis from alkenes are considered in Science of Synthesis, Vol. 40a [Amines and Ammonium Salts (Section 40.1.5.1.1)]. This section discusses the most useful methods currently available for stereoselective synthesis of aziridines from alkenes.

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References