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1.4 Aziridination

DOI: 10.1055/sos-SD-201-00070

Muchalski, H.; Johnston, J. N.Science of Synthesis: Stereoselective Synthesis, (20111155.

General Introduction

Aziridines are the smallest carbocycles containing one nitrogen atom. Due to their angle strain, they exhibit a synthetically useful balance between stability and reactivity. Thus, they are often employed as versatile intermediates. The ability of aziridines to undergo highly regio- and stereoselective ring-opening reactions makes them of great value in organic synthesis. The properties, synthesis, and applications of aziridines have been thoroughly reviewed.[‌1‌‌6‌] Methods for aziridine synthesis from alkenes are considered in Science of Synthesis, Vol.40a [Amines and Ammonium Salts (Section]. This section discusses the most useful methods currently available for stereoselective synthesis of aziridines from alkenes.

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