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1.5 Hydrogenation of Carbon—Carbon Double Bonds

DOI: 10.1055/sos-SD-201-00087

Ager, D.Science of Synthesis: Stereoselective Synthesis, (20111185.

General Introduction

The asymmetric hydrogenation of a C=C bond was the first transformation to achieve enantioselectivities approaching those of an enzymatic transformation. The work, by William Knowles at Monsanto resulted in him receiving the Nobel Prize in 2001.[‌1‌] Today, hydrogenation of C=C bonds is an industrial-scale transformation to introduce stereogenic centers.[‌2‌‌4‌] There are also a large number of catalyst systems available that have been developed to perform asymmetric hydrogenation on a wide range of substrate classes.[‌5‌,‌6‌]

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References