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DOI:
10.1055/sos-SD-201-00087
Ager, D., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 192.
Asymmetric hydrogenation reactions were first developed for the preparation of α-amino acid derivatives by the reduction of the corresponding acylated didehydroamino substrates. Further refinement has led to the possibility of other functionality being present in the substrate.