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1.12.2.4.2 Use of Ammonia Lyases

DOI: 10.1055/sos-SD-201-00304

Nguyen, B. N.; Hii, K. K.; Szymański, W.; Janssen, D. B.Science of Synthesis: Stereoselective Synthesis, (20111643.

Ammonia lyases are enzymes that catalyze the reversible addition of ammonia to double bonds. To date, over 20 such enzymes have been characterized and their properties have been reviewed.[‌171‌] Different mechanisms of action can be found within this family of enzymes, which require different internal or external cofactors, such as 4-methyleneimidazol-5-one (MIO), pyridoxal phosphate, coenzyme B12, or chelated metals. This review will focus on ammonia lyases and mutases for which synthetic utility has been reported.

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References


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