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Please login or sign up for a free trial to access the full content. Use of Other Enzymes

DOI: 10.1055/sos-SD-201-00304

Nguyen, B. N.; Hii, K. K.; Szymański, W.; Janssen, D. B.Science of Synthesis: Stereoselective Synthesis, (20111646.

l-Aspartate ammonia lyase (EC catalyzes the addition of ammonia to fumaric acid to give l-aspartic acid with very high enantioselectivity (Scheme 34), which is used for the synthesis of the artificial sweetener aspartame.[‌180‌]

Meeeee 88 Meeeeeeee-Meeeeeeee Meeeeeee ee Meeeeee ee Meeeeee Meee[‌888‌]

Meeeeeeeeeee ee eeee eeeeee ee eeeee eeeeeeeeee eee eeeeeeeeee, eeeee ee eee eeee eeee eeeeeeeee ee eee ee eee eeee eeeeeeee eeeeeee eeeee.[‌888‌] Meeeeee, eeeeeeee eeeeeeeee eeeeeee eeee eeeeeee eeeeeee ee ee eeeeeeee, eeee eeeeeeeee eeeeeeeee eeeeeeeeee[‌888‌] eee eeeeeeeee eeeeeeeee eeeee,[‌888‌] e.e. eeee eeeeeeeee eeeeeeee eeeeee eee eeeeeeeee ee eeeeeee eeee.

Meeeeeeee eeeeeeee eeee Meeeeeee eee. eee eeee eeeee ee eeeeeeee eee eeeeeeee ee eeeeeeeeeeee eeeee eeee eeeeeee ee eeeeeee eeee.[‌888‌] Meee eeeeeeeeee eee ee eeeeeeee eeee eeeeeeeeeeeee, eeeeeeeeeeee, eeeeeeeee, eee eeeeeeeeeee, eeee eeeeeee eeeeeeeeeeee eeeeee eeeeee eeee 88 ee >88%. Mee eeeeeeeee eee ee eeeeeeeee ee e eeeeeeeeeee eeeee, eeee ee eee eeeeeee eeeeeeeee ee Meeeee 88.

Meeeee 88 Meeeeeeee-Meeeeeeee Meeeeeee ee Meeeeeeeeee ee Meeeeee Meee[‌888‌]

Me eee eeeee eeee, e-eeeeeeeeeeeeeee eeeeeee eeeee (MMM, MM eeeeeeeee eee eeeeeeeeeeeeeeee eeeeeeee ee eeeeeee ee eeeeeeeee eeee [(M)-eeeeeeeeeeeeeeeee eeee] ee eeeeeee 8-eeeeeeeeeeeeee eeee ee eee eeeeeee. Mee eeeeeeeee ee eeee eeeeeeee eeeeeeee eeeeeeeeeeeee ee eee eeeeee eeeee eeeeee eee eeeeee eeeeee eeee, eeeeeeeeeeee eee eeeeeeee ee eeeeeee (Meeeee 88).[‌888‌]

Meeeee 88 8-Meeeeeeeeeeeeee-Meeeeeeee Meeeeeee ee Meeeeee ee Meeeeeeee Meee[‌888‌]

Mee eee ee 8-eeeeeeeeeeeeeee eee eee eeeeeeeee eeeeeeeee eeeeeeee ee eeeeeee eeeeee eeeeeee eeeeeeeeeeeee, ee eee eeeeeeeee eeeee ee eeee eeeeee ee eee eeeeeee ee eee eeeeeee eeeeeeeee eeeeeeeee eeee. Meee eee eeeeeeeeee ee 8-eeeeeeeeeee eeeeeee eeeee eee eeee eeeeeeeee,[‌888‌,‌888‌] eeeeeee ee eee eeeeeeeee ee e eeeeeee ee 8-eeeeeeeeeee eeeeeeee eeeee 88 eeeeeeeeee eeeeeee eee eeeee eeeeee (Meeeee 88). Me eeeee eeeeeeeee, eee ee eee eeeeeeeeeeeee ee eeeeee ee eee eeeee, eeeeeeeeeee eeeeeee. M eeeeee ee e-eeeeeeeeeeeeeee eeeeeee eeeee (MMM M888M) eee eeee eeeeeeee eeee eeeee eeeeeeeee eeeeeeeee- eee eeeeeeeeeeeeeeeeee eee eeeeeeeee eeee, eeeeeeeeee ee eeee eeeeeeeee eeee (8M,8M)-8-eeeeeeeeeeeeee eeee.[‌888‌]

Meeeee 88 8-Meeeeeeeeeeeeee-Meeeeeeee Meeeeeee ee Meeeeee ee 8-Meeeeeeeeee Meeeeee Meeee[‌888‌,‌888‌]

Meeeeeeeeee 88

M8 Meeee (%) Mee
M 88 [‌888‌]
Me 88 [‌888‌]
Me 88 [‌888‌]
Me 88 [‌888‌]
Me 88 [‌888‌]
eMe 88 [‌888‌]

Meeeeeeeeeee Meeeeeeee

(M)-8-(Meeeeeeeeee)eeeeeeeeeee eeee (88); Meeeeee Meeeeeeee:[‌888‌]

M eeee ee 8M MMe eee eeeee ee e 88% ee eeee ee MeMM8 (8.88eM, 88.8eeee) ee e 8 eM eeeeeeeee eeeeee eeee ee e Meeeeee eeee eeeee eM8.8 eee eeeeeee. M 888 eM eeeee eeee ee eeeeeee eeee (88eM, 8.88eeee) ee eM8.8 eee eeeee eee eee Meeeeee eeee eee eeeeee ee ee 88eM eeee 8 eM eeeeeeeee eeeeee (eM8.8). Meeee eeeeeeee ee MeeM (888µM, 8.888eeee) eeee e eeeeee eeeee, eee eeee eee eeeeee ee 888 eee ee 88°M eee 8e. Mee eeeeeee eee eeeeeeeeee eee eee eeeee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, MeMM/MeMMe/MeMM/M8M 8:8:8:8). Meeee eeeeeeeeeee ee eee eeeeeee eee eeeeeeeeeeeeee, eee eeeeeee eee eeeeeeee ee e eeeee eee; eeeee: 888ee (88%); >88% ee.

e-Meeeeeee Meee (88, M8=M); Meeeeee Meeeeeeee:[‌888‌]

Meeeeee eeee (8e, 88.8eeee) eee eeeeeeeee ee M8M (88eM) eee eee eM eee eeeeeeee ee 8 eeee eeeee MM8. Mee eeee eee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeeeeee eeeeeeee eee eeeeeeeeeee ee M8M (88eM), eeeeeeeee MeMe88M8M (88ee, 88eeee) eee MMe (8ee. 8.8eeee) eeee eeeee. Mee eM eee eeeee eeeeeeee ee 8 eeee eeeee MM8. Mee eeeeee 8-eeeeeeeeeeeeeee (88 eeeee) eee eeeee eee eee eeeeeeee eee eeeeeeeee ee 88°M eeeee ee eeeeeee eeeeeeee ee eeeeeeeeee ee 888ee eee eeeeeeee (8e). Mee eeeeeee eee eeeeeeeee ee 888°M eee 8eee eee eeeeeee ee eeeeeeeeee eeeeeee e eee ee Meeeee. Mee eeeeeeee eee eeeeeeeee ee eM8 eeee 88M MMe eee eee eeee eeeeeeeee eeee Me8M. Mee eM ee eee eeeeeee eeeee eee eeeeeeee ee eM8 eee e eeeee eeeeeeeeeeee eee eeee eee eeeeeeee ee MeMM. Mee eeeee eee eeeeeeeeeeeeee (eee M8M/MeMM) ee eeee eee eeeeeee; eeeee: 8.88e (88%).