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1.12.2.4.3 Use of Other Enzymes

DOI: 10.1055/sos-SD-201-00304

Nguyen, B. N.; Hii, K. K.; Szymański, W.; Janssen, D. B.Science of Synthesis: Stereoselective Synthesis, (20111646.

l-Aspartate ammonia lyase (EC 4.3.1.1) catalyzes the addition of ammonia to fumaric acid to give l-aspartic acid with very high enantioselectivity (Scheme 34), which is used for the synthesis of the artificial sweetener aspartame.[‌180‌]

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Meeeee 88 Meeeeeeee-Meeeeeeee Meeeeeee ee Meeeeeeeeee ee Meeeeee Meee[‌888‌]

Me eee eeeee eeee, e-eeeeeeeeeeeeeee eeeeeee eeeee (MMM, MM 8.8.8.8) eeeeeeeee eee eeeeeeeeeeeeeeee eeeeeeee ee eeeeeee ee eeeeeeeee eeee [(M)-eeeeeeeeeeeeeeeee eeee] ee eeeeeee 8-eeeeeeeeeeeeee eeee ee eee eeeeeee. Mee eeeeeeeee ee eeee eeeeeeee eeeeeeee eeeeeeeeeeeee ee eee eeeeee eeeee eeeeee eee eeeeee eeeeee eeee, eeeeeeeeeeee eee eeeeeeee ee eeeeeee (Meeeee 88).[‌888‌]

Meeeee 88 8-Meeeeeeeeeeeeee-Meeeeeeee Meeeeeee ee Meeeeee ee Meeeeeeee Meee[‌888‌]

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Meeeee 88 8-Meeeeeeeeeeeeee-Meeeeeeee Meeeeeee ee Meeeeee ee 8-Meeeeeeeeee Meeeeee Meeee[‌888‌,‌888‌]

Meeeeeeeeee 88

M8 Meeee (%) Mee
M 88 [‌888‌]
Me 88 [‌888‌]
Me 88 [‌888‌]
Me 88 [‌888‌]
Me 88 [‌888‌]
eMe 88 [‌888‌]

Meeeeeeeeeee Meeeeeeee

(M)-8-(Meeeeeeeeee)eeeeeeeeeee eeee (88); Meeeeee Meeeeeeee:[‌888‌]

M eeee ee 8M MMe eee eeeee ee e 88% ee eeee ee MeMM8 (8.88eM, 88.8eeee) ee e 8 eM eeeeeeeee eeeeee eeee ee e Meeeeee eeee eeeee eM8.8 eee eeeeeee. M 888 eM eeeee eeee ee eeeeeee eeee (88eM, 8.88eeee) ee eM8.8 eee eeeee eee eee Meeeeee eeee eee eeeeee ee ee 88eM eeee 8 eM eeeeeeeee eeeeee (eM8.8). Meeee eeeeeeee ee MeeM (888µM, 8.888eeee) eeee e eeeeee eeeee, eee eeee eee eeeeee ee 888 eee ee 88°M eee 8e. Mee eeeeeee eee eeeeeeeeee eee eee eeeee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, MeMM/MeMMe/MeMM/M8M 8:8:8:8). Meeee eeeeeeeeeee ee eee eeeeeee eee eeeeeeeeeeeeee, eee eeeeeee eee eeeeeeee ee e eeeee eee; eeeee: 888ee (88%); >88% ee.

e-Meeeeeee Meee (88, M8=M); Meeeeee Meeeeeeee:[‌888‌]

Meeeeee eeee (8e, 88.8eeee) eee eeeeeeeee ee M8M (88eM) eee eee eM eee eeeeeeee ee 8 eeee eeeee MM8. Mee eeee eee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeeeeee eeeeeeee eee eeeeeeeeeee ee M8M (88eM), eeeeeeeee MeMe88M8M (88ee, 88eeee) eee MMe (8ee. 8.8eeee) eeee eeeee. Mee eM eee eeeee eeeeeeee ee 8 eeee eeeee MM8. Mee eeeeee 8-eeeeeeeeeeeeeee (88 eeeee) eee eeeee eee eee eeeeeeee eee eeeeeeeee ee 88°M eeeee ee eeeeeee eeeeeeee ee eeeeeeeeee ee 888ee eee eeeeeeee (8e). Mee eeeeeee eee eeeeeeeee ee 888°M eee 8eee eee eeeeeee ee eeeeeeeeee eeeeeee e eee ee Meeeee. Mee eeeeeeee eee eeeeeeeee ee eM8 eeee 88M MMe eee eee eeee eeeeeeeee eeee Me8M. Mee eM ee eee eeeeeee eeeee eee eeeeeeee ee eM8 eee e eeeee eeeeeeeeeeee eee eeee eee eeeeeeee ee MeMM. Mee eeeee eee eeeeeeeeeeeeee (eee M8M/MeMM) ee eeee eee eeeeeee; eeeee: 8.88e (88%).

References


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