Science of Synthesis

Reznichenko, A. L.; Hultzsch, K. C., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 689.

General Introduction

The direct hydrofunctionalization of unsaturated C—C bonds is an attractive route to introduce a heterofunctionality into the molecular skeleton. Thus the direct addition of an amine N—H or compounds having a P—H bond [i.e., by hydrophosphination (addition of a phosphine), hydrophosphinylation (addition of a dialkylphosphine oxide), or hydrophosphonylation (addition of a dialkyl phosphonate)] across an unsaturated C—C linkage represents an attractive and highly atom-economical access route to amines and phosphines in an intermolecular or intramolecular fashion (‌Scheme 1‌).

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References