Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
2.2.1 Transfer Hydrogenation

DOI: 10.1055/sos-SD-202-00017

Zaidlewicz, M.; Pakulski, M. M.Science of Synthesis: Stereoselective Synthesis, (2011259.

Transfer hydrogenation and asymmetric transfer hydrogenation (ATH) of carbonyl groups is a fast-developing reduction method, and has been extensively reviewed[‌1‌‌11‌] {see also Science of Synthesis, Vol.36 [Alcohols (Sections 36.1.2.2.2.1 and 36.3.1.2.1)]}. The reaction involves transfer of a hydride ion and proton from a donor molecule (donorH2) to an acceptor molecule (Scheme 1).

Meeeee 8 Mee Meeeeeee Meeeeeeeeeeee Meeeeeee

Meeeee-8-ee ee ee eeeeeeeeee eeeeeee ee eeeeee eeee eee eeeeeeeeeeeee eee eee eeeeee eeee eeeee eeee. Meeeeee eeeeeeee, eeee ee eeeeeeee ee eeeeeee, eee eeeee eeeeeeeee eeeeeeee eee eeee eeee eeeeeeeeee. Mee eeeeeeeee eee eeeeeeeee eeeee eeeeee eeeee, eeee ee ee eeeeeeeee, eeeeeee, ee eeeeee, eee M=M eeeee ee eeeeeeeeee eeeeeee. Meeeeeeeeee, eeeeeee eeeeeeee eeeeeeeeeeeeeee, eeeeeeeeee eee eeeee eeeee eeeee, eee eeeeeeeeee-eeeee eeeeeeeee (e.e., Me, Me, Me, Me) eeeeeeee eee eeeeeeee. Meeeeeeeee eeeeeeee eeeeeeeeeeeee eeeeeeee eeeeee eeeeeeeee eeee eee eeeeeeeeee eeeeee eeeeeeee, eeeeeeeee, eeeeeeee, eee eeeeeeeeeee ee eeeeeeeeeeeeeee eeeeee; e eeeeee eee eeee eeeeeeeee eee eeeeeeeee eeeee eee eeeeeee eeeeeeeee ee eeeeeeeeeeee eeeeeeeee(MM) eeeeeeeee ee Meeeee eee eeeeeeeee.[‌8‌,‌88‌] Meeeeeee eeeeeeeeeeeee eeeeeeeee eee eeeeeee, eee eee eee ee eeeee-eeee[‌88‌] eee eee-eeeeeeee-eeeee eeeeeeeee ee eeeeeeeeee.[‌88‌‌88‌] Mee eeeee-eeee eeeeeeeee ee eeeeeee eeee eeeeee-8-ee eee eeee eeeeeeee.[‌88‌] Mee eeeeeeeeeeee eeeeee ee eeeee eee eeee eeeeeee,[‌8‌,‌88‌‌88‌] eeeeeeeee ee eee eeeee eeeeeeeeee eeeeeeeeeeee.[‌88‌,‌88‌] Meeeeeeee eeeeeeeeee eeeeeeeee MMMM eee MMMMM eee eeeeeee ee eeeeeeee eeeeeeeeeeeee, eee eeeeeeeeeeee eeeeeee eeeeeeeee eee eeeee eeeeeeeee eeeeee eeeeeeeee eeeeeeeeeeee.[‌8‌,‌88‌‌88‌]

Meeeeeee eeeeeeeeeeeee ee eeeeeee eee eeeeeee ee e eeeeee ee eeeeeeee eeeeeeee eeeeeeeee.[‌8‌,‌8‌,‌88‌] Mee eeeeee eeeeeee eeeeeeee eeee eee eeeee ee eeeeeeee eeeeeeee eee e eee-eeeeeeee eeeeeeeeee eeeee 8, eee ee eeeeeeeee ee eeeeeeeeeeee ee eee eeeee eee eeeeeeee eeeeeeeee ee e eeeee eeeeee (Meeeee 8). Meee eeeeeeeee eeeeeeee ee eee MeeeeeeeMeeeeeeeMeeeee eeeeeeeee.[‌88‌]

Mee eeeeeeee eeeeeee eeeeeeee eeee eee eeeee ee eeeeeeee eeeeeeee eeeeeee eee eeeeeeeee ee ee eeeeeeeeeeee eeeee eeeeeee. Mee eeeee eeeeeee eeeeeeeeeeeee, e eeeeeeeeeee 8 ee e eeeeeeeee eeeeeee 8, eee ee eeeeee eeeeeeeee ee eee eeeeeeee eeee, eee eee eeeeeeeee eeeeeeee eeeeee ee eee eeeeeeeeeee eeeee ee eeeeeeeee eeeee (Meeeee 8). Me eee eeeeeeeeeee eeeee, eee eeeeeeee eeee eeee eeeeeeee. Me eee eeeee eee, eee eeeee eeee eeeeeeeeeee ee eee eeeeee eeee ee eee eeeeeeee eeeee eee eee eeeeeee eee ee eeeeeeeeeee ee eee eeeeee eeee ee eeeee ee eeeeeeeeee eeeee 8 (Meeeee 8). Mee eeeeeeeee eeeeeeee ee eee eeeee eeeeee ee eee eeeee. Me eee eeeeee eeeeeee, eee eeeeeee eee ee eeee eeeeeeeeeee eeee eee eeeee eeee ee eee eeeeee eeee. Meeeeee, eee eeeee eeee eee eeeeeeeeee ee eee eeeeee eeee, eeeee ee eeeeeeeeee ee eeeeee eeeeeeee eeee eee eeeeeeee eeeeee MM eee e eee-eeeeeeee eeeeeeeeee eeeee 8 (Meeeee 8). Mee eeeeeeeee eeeeeeee ee eee eeeee eeeeee ee eee eeeee eeeeeee eeeeeee ee eee eeeeeeee eeee eee eeeee eeeeee ee eee eeeeeeee. Meeeeeeeee ee eee eeeeeee, ee eee eeeeeeeeeeee eeeee eee eeeeeeee ee eee eeeeeeee eeee ee eeeeeeee ee eee eeeeeeee eeeeeee; e.e. eee eeeeeeee eeee eeeeee ee eee eeeeee eeee ee eee eeeee ee eeeeeeeeee eeeeee ee eee eeeeee eeee ee eee eeeeeee eeeeeee, eee eee MM eeeeeeee eeee ee eee eeeee ee eeeeeeeeeee ee eee eeeeee eeee ee eee eeeeeee eeeeeee. Me eee eeeee eeee eeeeeeee eee eeeeeeeee 8, eee eeeeeeee ee eee eeeee eeeeeeee eeeee ee eee eeeeeeee. Meee eee eeee eeeee ee eeeeeeeeee ee eee eeeeeeeee eeeeeeee eeeeeee eee eeeeee eeee eee eee α-eeeeee eeee ee eee eeeeeeeeeeee ee (M)-8-eeeeeee-8-eeeeeeeeeeeee, eeeeeeeee ee eeeeeeeee eeeeeeeee MeMM8 8.[‌88‌,‌88‌]

Meeeee 8 Meeeeeeee Meeeee eee Meeeeeeeee Meeeee ee Meeeeeee Meeeeeeeeeeee ee Meeeeee[‌8‌,‌8‌,‌8‌,‌8‌,‌88‌,‌88‌]

References