Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
2.3.4.3 Dialkyl, Alkyl Alkenyl, and Alkyl Alkynyl Ketones

DOI: 10.1055/sos-SD-202-00041

De Wildeman, S.; Sereinig, N.Science of Synthesis: Stereoselective Synthesis, (20112169.

Numerous examples of enzymatic reductions of ketones bearing hydrophobic alkyl, alkenyl, and alkynyl groups are described in Table 10.

Meeee 88 Meeeeeeee ee Meeeeee, Meeee Meeeeee, eee Meeee Meeeeee Meeeeee[‌88‌,‌88‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌‌888‌]

M8 M8 Meeeeee,e Meeeeee Meeeee ee (%) Meeeee (%) Mee
Me Me M Mee-MMM8 M 88 88 [‌888‌]
Me MM(MMe)8 M MMM-MM M >88 88 [‌888‌]
Me Me M Mee-MMM8 M >88 8888 [‌888‌]
Me Me M MMM-M M >88 e.e. [‌88‌]
Me Me M MMM-MM M >88 88 [‌888‌]
Me eMe M Mee-MMM8 M >88 88 [‌888‌]
Me Me M Mee-MMM8 M 88 88 [‌888‌]
Me Me M MMM-M M >88 e.e. [‌88‌]
Me Me M MMM-MM M 88 e.e. [‌888‌]
Me Me M MMM-MM M >88 88 [‌888‌]
Me eMe M MMM-MM M 88 e.e. [‌888‌]
Me (MM8)8Me M MMM-MM M >88 88 [‌888‌]
Me (MM8)8Me M MMM-MM M >88 eeeeeee [‌88‌]
Me (MM8)8Me M MM-eeeee M >88 88e [‌888‌]
Me (MM8)8Me M MMM M 888 88888 [‌888‌]
Me (MM8)8Me M Mee-MMM8 M 88 88 [‌888‌]
Me (MM8)8Me M MMM888e M 88 eeee [‌888‌]
Me (MM8)8Me M MMM-M M >88 e.e. [‌88‌]
Me (MM8)8Me M MMM-MM M 88 e.e. [‌888‌]
Me (MM8)8Me M MMM-MM M >88 >88e [‌888‌]
Me (MM8)8Me M MMM-MM M >88 eeee [‌88‌]
Me (MM8)8Me M MM-eeeee M >88 88e [‌888‌,‌888‌]
Me (MM8)8Me M MMM M 888 88888 [‌888‌]
Me (MM8)8Me M MMM-MM M >88.8 >88 [‌888‌]
Me (MM8)8Me M MMM-M M >88 e.e. [‌88‌]
Me (MM8)8Me M Mee-MMM8 M 88 >88 [‌888‌,‌888‌]
Me (MM8)8Me M MMM888e M 88 eeee [‌888‌]
Me (MM8)8Me M MMM-MM M >88 >88e [‌888‌]
Me (MM8)8Me M MMM-MM M 88 e.e. [‌888‌]
Me (MM8)8Me M MMM-MM M >88 eeee [‌88‌]
Me (MM8)8Me M MM-eeeee M >88 88e [‌888‌]
Me (MM8)8Me M Mee-MMM8 M 88 >88 [‌888‌,‌888‌]
Me (MM8)8Me M MMM-MM M 88 eeee [‌888‌]
Me (MM8)8Me M MM-eeeee M >88 88e [‌888‌,‌888‌]
Me (MM8)8Me M Mee-MMM8 M 88 >88 [‌888‌,‌888‌]
Me (MM8)8Me M MMM-MM M 88 eeee [‌888‌]
Me (MM8)8Me M Mee-MMM8 M >88 >88 [‌888‌,‌888‌]
Me Me M MM-eeeee M >88 88e [‌888‌,‌888‌]
Me 8-eeeeeeeee M MMM-MM M >88 eeee [‌88‌]
Me eeeeeeeeeee M MMM-MM M 88 e.e. [‌888‌]
Me eeeeeeeeeee M Mee-MMM8 M 88 88 [‌888‌]
Me eeeeeeeeeee M MMM-MM M >88 88 [‌888‌]
Me (MM8)8MM8Me M MMM888e M 88 88 [‌888‌]
Me (MM8)8MM8Me M MM-MMM M >88 88 [‌888‌]
Me (MM8)8Me M MMM-MMee M 88 e.e. [‌888‌]
Me (MM8)8Me M MMM-MM-MMM M 88 88 [‌888‌]
Me (MM8)8Me M MMM-MM M >88 88 [‌888‌]
Me (MM8)8Me M MMM-MM M 88 e.e. [‌888‌]
Me (MM8)8Me M Mee M 88 >88 [‌888‌]
Me (MM8)8Me M MMM-MM M 88 e.e. [‌888‌]
Me (MM8)8MM8Me M MMM-MM M >88.8 e.e. [‌888‌]
Me (MM8)8MM8Me M MMM-MM M 88 eeeeeee [‌888‌]
Me (MM8)8MM8Me M MMM-MM M >88 eeeeeee [‌888‌]
Me (MM8)8MM8Me M MMM-MM M >88 eeee [‌888‌]
Me (MM8)8MM M MMM-MM M 88 eeee [‌888‌]
Me (MM8)8MM M MMM-MM M 88 eeeeeee [‌888‌]
Me (MM8)8MMe M MMM-MM M 88 eeeeeee [‌888‌]
Me MM8 M MMM-MM M 88 888e [‌888‌]
Me MM8 M MMM-M-MM-8 M 88 888e [‌888‌]
Me MM8MM8 M MMM-MM M 88 88e [‌888‌]
Me MM8MM8 M MMM-M-MM-8 M >88 888e [‌888‌]
Me Me M Mee M 88 88 [‌888‌]
Me Me M MMM-MM M 88 e.e. [‌888‌]
Me Me M MMM-MM M 88 eeee [‌888‌]
Me (MM8)8Me M MMM-MM M >88 eeee [‌88‌]
Me (MM8)8Me M MM-eeeee M >88 88e [‌888‌,‌888‌]
Me (MM8)8Me M MMM-MM-M M >88 88e [‌888‌]
Me (MM8)8Me M MMM-Mee M 88 eeeeeee [‌888‌]
Me (MM8)8Me M MMM-Mee M 88 eeee [‌888‌]
Me (MM8)8MM8Me M MMM-MM M 88 eeeeeee [‌888‌]
MM8 (MM8)8Me M Mee M 88 >88 [‌888‌]
MM8 (MM8)8Me M Mee M 88 >88 [‌888‌]
MM8 (MM8)8Me M Mee M 88 >88 [‌888‌]
MM8 (MM8)8Me M Mee M 88 >88 [‌888‌]
MM8Me Me M MM-MMM M >88 88 [‌888‌]
MM8Me (MM8)8Me e.e. MM-eeeee M 88 >88e [‌888‌]
MM8Me (MM8)8Me M MMM-MM-M M >88 >88e [‌888‌]
MM8Me (MM8)8Me M MMM-MM M >88 >88 [‌888‌]
MM8Me (MM8)8Me M MMM-MM M >88 >88 [‌888‌]
e-Me MM8MM e.e. MMM888e M 88 88 [‌888‌]
MM=MM8 (MM8)8MM8Me M MMM-MM M >88 88 [‌888‌]
e-Me MM8MM e.e. MMM-MM M 88 88 [‌888‌]
MM8MMe (MM8)8Me M MMM888e M 88 88 [‌888‌]
MM8MMe (MM8)8Me M MM-MMM M >88 88 [‌888‌]
MM=MM8 (MM8)8Me M MMM-MM-M M >88 88e [‌888‌]
MM=MM8 (MM8)8MM8Me M MMM-M M 88 88 [‌888‌]
Me (MM8)8MM=MMe8 eeeeeee MMM-MM M >88 e.e. [‌888‌,‌888‌]
Me (MM8)8MM=MMe8 M MM-eeeee M >88 88e [‌888‌,‌888‌]
Me (MM8)8MM=MMe8 M Mee-MMM8 M >88 >88 [‌888‌]
Me (MM8)8MM=MMe8 M MMM-MM-MMM M 88 88 [‌888‌]
Me (MM8)8MM=MMe8 M MMM-MM M >88 88 [‌888‌]
Me (M)-MM=MMMe M MM-eeeee M >88 8888e [‌888‌,‌888‌]
Me (M)-MM=MMMe M MMM-MM-M M >88 88 [‌888‌]
Me (MM8)8MM=MM8 M MMM-MM M 88 eeeeeee [‌888‌]
Me (M)-(MM8)8MM=MMMe M MMM-MM M 88 eeeee [‌888‌]
Me (MM8)8MM=MM8 M MMM-MM M 88 eeeeeee [‌888‌]
Me (MM8)8M(Me)=MM8 M MMM-MM M >88 eeee [‌888‌]
Me M MMM-MM M 88 eeeeeee [‌888‌]
Me (MM8)8MMM M MMM-MM M >88 eeeeeee [‌888‌]
Me (MM8)8MMMe M MMM-MM M 88 eeeeeee [‌888‌]
Me (MM8)8MMMe M MMM-MM M 88 eeeeeee [‌888‌]
Me (MM8)8MMM M MMM-MM M >88 eeeee [‌888‌]
Me (MM8)8MMM M MMM-MM M >88 eeee [‌888‌]
Me M MM-eeeee M >88 88e [‌888‌]
Me (M)-MM=MMMe M MM-eeeee M >88 88e [‌888‌]
MM8Me (MM8)8MM=MM8 M MM-MMM M >88 88 [‌888‌]
MM8MMe (MM8)8MM=MM8 M MMM888e M 88 88 [‌888‌]
MM8MMe (MM8)8MM=MM8 M MM-MMM M >88 88 [‌888‌]

e Meeeee M: eeeeeeee eeeeeeeeeeee eeee eMeMM; Meeeee M: eeeeeeee eeeeeeeeeeee eeee MMM; Meeeee M: eeeeeeee eeeeeeeeeeee eeee MMM; Meeeee M: MMM eeeeeeeeeee eeee MMM; Meeeee M: eeeeeeee eeeeeeeeeeee eeee eeeeeee-8-eeeeeeeee eeeeeeeeeeeee; Meeeee M: MMM eeeeeeeeeee eeee MMM; Meeeee M: eeeeeeee eeeeeeeeeeee eeee eeeeeeeeeeeee

e e.e.=eee eeeeeeee.

e MMM-MM=Meeeeee eeeeeeeee eeeeeee eeeeeeeeeeeee; MMM-MM=Meeeeee eeeeeeeeeeee eeeeeee eeeeeeeeeeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeee eeeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeee eeeee; MMM-MM=Meeeeeeee eeeeeee eeeeeeeeeeeee; MMM-MMee=eeeeeee eeeeeeeeeeeee eeee Meeeee eeeeeeeeee ee M. eeee; MMM-MM-MMM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeee ee. eeeeee MMM; MMM-Mee=eeeeeee eeeeeeeeeeeee eeee Meeeeeeee ee.; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeee eeeeeeeeeeee; MMM-M-MM8=MM-8 eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeee ee.; MMM-MM-M=eeeeeee eeeeeeeeeeeee-M eeee Meeeeeeeeee eeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeeee eeeeeeeeeeee MMM 8888 ee M. eeee; MMM-M=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeeeeeeee ee.; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeeeeee eeeeeee; Mee=eeeee eeeee ee Meeeeeeeee eeeeeeee; Mee-MMM8=eeeee eeeee ee Meeeeeeeee eeeeeeee (MMM8); MMM=eeeeeeeeeeeeeeeeee eeeeeeeee eeee Meeeeeeeeeeeeee; MM-eeeee=Meeeeeeeeee eeeee eeeee; MM-MMM=eeeeeeee eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeee eeeeeeeeee (eeeeeʼe eeeee); MMM888e=MMM888e eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeee eeeeeeeeee (eeeeeʼe eeeee) ee M. eeee; MMM888e=MMM888e eeeeeee eeeeeeeee MMM eeee Meeeeeeeeeeee eeeeeeeeee (eeeeeʼe eeeee).

e Meeeeeee.

e Meeeeeeeee.

Meeeee eeeeeeeeeee eeeeeeee ee eeeeeeeee ee Meeee 88 eee eeeeeeeee eeeeeeee eeeeee eee eeeeeeeee.

Meeee 88 Meeeeeeee ee Meeeeeeeeee Meeeeee[‌88‌,‌88‌,‌888‌,‌888‌,‌888‌]

M8 M8 M8 Meeeeee,e Meeeeee Meeeee ee (%) Meeee (%) Mee
M M Me M MMM-MM M >88 >88 (eeeee) [‌88‌,‌88‌,‌888‌]
M M Me e.e. MMM-MM M >88 eeeeeee [‌88‌,‌88‌]
M M Me e.e. MMMMM M >88 eeee [‌88‌,‌88‌]
M M Me M MMM-MM M >88 8888 [‌888‌]
M M 8-MeMM8M8 M MMM-MM M >88 >88 [‌888‌]
M M 8-MeMM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MM8M8 M MMM-MM M >88 888e [‌888‌]
M M 8-MM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 888e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 >88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-MeM8M8 M MMM-MM M >88 88e [‌888‌]
M M 8-eeeeeee M MMM-MM M >88 888e [‌888‌]
M M 8-eeeeeee M MMM-MM M >88 88e [‌888‌]
M M M MMM-MM M >88 888e [‌888‌]
M M M MMM-MM M >88 88e [‌888‌]
M M MMM M MMM-MM M >88 888e [‌888‌]
M M MMM M MMM-MM M >88 88e [‌888‌]
M M MMMMM M MMM-MM M >88 88e [‌888‌]
M M MMMMM M MMM-MM M 88.8 88e [‌888‌]
M M MeMe8Me M MMM-MM M >88 88e [‌888‌]
M M MeMe8Me M MMM-MM M >88 88 [‌88‌,‌888‌]
M M e.e. MMM-MM M 88 88e [‌88‌]
M M e.e. MMM-MM M >88 88e [‌88‌]
M M e.e. MMMMM M 88 88e [‌88‌]
Me M Me e.e. MMM-MM M >88 eeeeeee [‌88‌,‌88‌]
Me M Me e.e. MMMMM M >88 88 [‌88‌,‌88‌]
Me M Me M MMM-MM M >88 88 [‌88‌,‌88‌]
Me M MMMMM e.e. MMM-MM M >88 eeeeeee [‌88‌,‌88‌]
Me M MMMMM e.e. MMMMM M >88 eeeeeee [‌88‌,‌88‌]
Me M MMMMM e.e. MMM-MM M >88 eeeeeee [‌88‌,‌88‌]
Me M MMM e.e. MMM-MM M >88 eeeee [‌88‌,‌88‌]
Me M MMM e.e. MMMMM M >88 eeee [‌88‌,‌88‌]
Me M MMM e.e. MMM-MM M >88 eeeeeee [‌88‌,‌88‌]
Me M MMM e.e. MMM-MM M >88 eeee [‌88‌,‌88‌]
Me M MMM e.e. MMMMM M >88 eeeeeee [‌88‌,‌88‌]
Me M MMM e.e. MMM-MM M >88 eeee [‌88‌,‌88‌]
Me M Me M MM-eeeee M >88 88e [‌888‌]
Me M M M MMM-MM M >88 88888 [‌88‌,‌888‌]
Me M M M MMM-MM M >88 888e [‌88‌,‌888‌]
MM8MM8eMe M M M MMM-MM M >88 88 [‌888‌]
(MM8)8MM8Me M M M MMM-MM M 88 88 [‌888‌]
(MM8)8MM8eMe M M M MMM-MM M >88 88 [‌888‌]
(MM8)8MM8Me M M M MMM-MM M >88 88 [‌888‌]
MM8MM8Me M MMM e.e. MMM-MM M 88 88e [‌88‌]
Me Me M e.e. MMM-MM M >88 88 [‌888‌]

e Meeeee M: eeeeeeee eeeeeeeeeeee eeee eMeMM; Meeeee M: eeeeeeee eeeeeeeeeeee eeee MMM.

e e.e.=eee eeeeeeee.

e MMM-MM=Meeeeee eeeeeeeeeeee eeeeeee eeeeeeeeeeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeee eeeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeee eeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeeeeee eeeeeee; MMM-MM=eeeeeee eeeeeeeeeeeee eeee Meeeeeeeeeeeeeeeee eeeeeeeeeee; MMMMM=eeeee eeeee eeeeeee eeeeeeeeeeeee; MM-eeeee=Meeeeeeeeee eeeee eeeee.

e Meeeeeee.

e Meeeeeeeee.