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2.5.2.1 Asymmetric Transfer Hydrogenation of Imines with Metal Catalysts in Organic Media

DOI: 10.1055/sos-SD-202-00095

Xu, L.; Wu, X.; Xiao, J.Science of Synthesis: Stereoselective Synthesis, (20112269.

The first well-designed chiral metal complex that catalyzes efficient asymmetric transfer hydrogenation of imines was demonstrated in 1996. The ruthenium-based catalyst enables asymmetric transfer hydrogenation with inexpensive formic acid under mild conditions.[‌68‌] Other metal complexes, in particular those of rhodium and iridium, have since been prepared and shown to be effective as well.

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