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2.5.5.1 Asymmetric Hydrosilylation of Imines with Metal Catalysts

DOI: 10.1055/sos-SD-202-00095

Xu, L.; Wu, X.; Xiao, J.Science of Synthesis: Stereoselective Synthesis, (20112283.

The chiral titanocene precatalyst 58 works efficiently in asymmetric hydrosilylation, reducing a wide range of imines, such as N-alkylimines, N-arylimines, and cyclic imines, in over 90% enantiomeric excess (Scheme 36).[‌90‌‌92‌] As in the case of titanocene precatalyst 29 (Scheme 11), an activation step is needed, in which 58 is converted into a catalytically active hydride species with phenylsilane.

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References