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Please login or sign up for a free trial to access the full content. Asymmetric Direct Reductive Amination of β-Keto Amides

DOI: 10.1055/sos-SD-202-00095

Xu, L.; Wu, X.; Xiao, J.Science of Synthesis: Stereoselective Synthesis, (20112291.

β-Amino amides are important intermediates in drug synthesis. Asymmetric direct reductive amination of β-keto amides allows direct access to such compounds and so would be more efficient than asymmetric hydrogenation of β-enamine amides.[‌115‌‌118‌] Simple ammonium salts as the nitrogen source are particularly attractive from an environmental and economical viewpoint.[‌119‌]

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