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2.10.1.1.1 Stoichiometric Zinc(II)-Mediated Enantioselective Alkynylations

DOI: 10.1055/sos-SD-202-00247

Carreira, E. M.; Frantz, D. E.Science of Synthesis: Stereoselective Synthesis, (20112499.

The preferred method for the enantioselective addition of terminal alkynes to aliphatic aldehydes is the method developed by the Carreira group.[‌13‌‌16‌] This strategy involves the use of stoichiometric amounts of zinc(II) trifluoromethanesulfonate, N-methylephedrine (1), and triethylamine at room temperature in toluene (Scheme 4).

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References


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