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DOI: 10.1055/sos-SD-202-00247

Carreira, E. M.; Frantz, D. E.Science of Synthesis: Stereoselective Synthesis, (20112499.

The preferred method for the enantioselective addition of terminal alkynes to aliphatic aldehydes is the method developed by the Carreira group.[‌13‌‌16‌] This strategy involves the use of stoichiometric amounts of zinc(II) trifluoromethanesulfonate, N-methylephedrine (1), and triethylamine at room temperature in toluene (Scheme 4).

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Meeee M8 M8 Meee (e) Meeeee (%) ee (%) Mee
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8 e-Me Me 8 88 88 [‌88‌]
8 e-Me (MM8)8Me 8 88 88 [‌88‌]
8 MM8e-Me (MM8)8Me 8 88 88 [‌88‌]

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