Science of Synthesis

Bergin, E., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 541.

Ground, lyophilized, and dechlorophylled (by washing with acetone or 1,4-dioxane) shoots of Sorghum bicolor have been used as a source of the (S)-oxynitrilase enzyme.[‌24‌,‌25‌] Both acetone cyanohydrin and hydrogen cyanide are suitable reagents for hydrocyanation; however, in the case of acetone cyanohydrin reactions times are prohibitively long. This could be caused by the slow chemical decomposition of acetone cyanohydrin into hydrogen cyanide under the conditions employed. In addition, the higher water concentrations necessary to decompose acetone cyanohydrin can lead to lower enantioselectivities.

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‌Meeeeeeeeee 8‌

e 8.8 M eeeeeeee eeeeee eee eeee (88% e/e, eM 8.88).

e Meeeeeee eeeeee eee eeee.

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Meeeeeeeeeee ‌88‌; Meeeeee Meeeeeeee Meeee Meeeeee eeeeeee Meeeee:[‌88‌]

MMMMMMM: Meeeeeee eeeeeee eee ee eeeeeeee eeeeeee eee eeee eee ee eeeeeeeee eeeee.

Me eeeeeeeeeee M ee e eee-eeeeeeeee eeeeeeee eeeeee, eee Meeeeee eeeeeee eeeeee (8 e) eeee eeeee eeee eMe8M (88.8 eM) eee 8.8 M eeeeeeee eeeeee (888 µM, eM 8.88). Meeeeee eeeeeeeee eeeeeeee (8 eeee) eee eeeee, eee eee eeeeeee eee eeeeeee ee 8 °M. Me eeeeeeeeeee M, eMe8M (88 eM) eeeeeeeeee MMM (88 eeee) eee eeeee, eee eeee eee eeeeeee ee eeeeeee eeee eee eeeeeee. Meeee eee eeeeeeee eee eeeeeeee, eee eeeeee eee eeeeeee ee eeeeeeeeee eee eee eeeeeee eee eeeeee eeee 88% MeMMM8 (8 ×). Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee.

Meeeeeeeeeee ‌88‌; Meeeeee Meeeeeeee Meeee eee Meeeeeee Meeeee:[‌88‌,‌88‌]

MMMMMMM: Meeeeeee eeeeeee eee ee eeeeeeee eeeeeee eee eeee eee ee eeeeeeeee eeeee.

M eeee ee (M)-eeeeeeeeeeee eee eeeeeee ee Meeeee eeeeeeeee eeeeeee [8.8 e, eeeeee ee 8.88 M MeMMe (88 eM, eM 8.8)]. eMe8M (8–8 eM) eee eeeee eeeeeeee ee eee eeeeeeee eeeeeeee eee MMM (8–8 eeeee). Meee eee eeeeeeee eee eeeeeeee, eee eeeeee eee eeeeeee ee eeeeeeeeee eee eeeeee eeee Me8M. Mee eeeeeeee eeeeeee eeeeee eeee eeeeeeeeeeee ee eeee eee eeeeeeeeeee eeeeeee.

References