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2.12.1 Asymmetric Mukaiyama Aldol Reaction Using Chiral Aldehydes or Chiral Silyl Enol Ethers

DOI: 10.1055/sos-SD-202-00309

Liu, L.; Wang, D.; Li, C. -J.Science of Synthesis: Stereoselective Synthesis, (20112599.

Under achiral Lewis acid catalysis, the asymmetric Mukaiyama aldol reaction can be performed by using a chiral aldehyde or a chiral silyl enol ether to give enantioenriched aldol adducts with high diastereoselectivity.