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DOI: 10.1055/sos-SD-202-00309

Liu, L.; Wang, D.; Li, C. -J.Science of Synthesis: Stereoselective Synthesis, (20112599.

Diastereoselective Mukaiyama aldol reaction of chiral aldehydes (e.g., 57) with silyl ketene acetals can be catalyzed by achiral Lewis acids. The configuration of the newly generated chiral center relies strongly upon the chiral center already existing in the starting chiral aldehyde. The reaction provides an efficient access to enantioenriched dihydroxy ketone derivatives (e.g., 58/59) in excellent diastereoselectivity (Scheme 25).

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