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2.12.2.1 Reactions with Chiral Titanium Catalysts

DOI: 10.1055/sos-SD-202-00309

Liu, L.; Wang, D.; Li, C. -J.Science of Synthesis: Stereoselective Synthesis, (20112602.

Enantioselective processes utilizing chiral titanium(IV) complexes have proved to be some of the most powerful transformations available to organic chemists. The addition of O-silyl O-alkyl ketene acetal 8 to aldehydes in the presence of only ca. 25mol% of 1,1-bi-2-naphthol-based titanium(IV) catalyst 25, which can be prepared from binaphthyl derivative 64 and carboxylic acid 65, yields the aldol products, such as 66, with excellent enantioselectivity (Scheme 28).[‌24‌]

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