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2.12.2.6 Reactions with Chiral Scandium Catalysts

DOI: 10.1055/sos-SD-202-00309

Liu, L.; Wang, D.; Li, C. -J.Science of Synthesis: Stereoselective Synthesis, (20112607.

The asymmetric Mukaiyama aldol reaction of silyl enol ethers (e.g., 80) with ethyl glyoxylate (81), catalyzed by the scandium complex 31 (see Scheme 13, Section 2.12), to give aldol adducts such as 82 is employed as the key step in an efficient enantioselective synthesis of α-hydroxy-β,β-dialkyl-γ-substituted pantolactones (e.g., 83) (Scheme 35).[‌62‌]

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Meeee (8M)-(8-Meeeeeeeeeeeeeeeee)-8-eeeeeeeeeeeeee (88); Meeeeee Meeeeeeee:[‌88‌]

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