Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
2.12.3.2 Brønsted Acid Catalyzed Reactions

DOI: 10.1055/sos-SD-202-00309

Liu, L.; Wang, D.; Li, C. -J.Science of Synthesis: Stereoselective Synthesis, (20112611.

Under catalysis by a disulfonimide (e.g., 38), 2-methylpropanoate- and acetate-derived ketene acetals (e.g., 91) react with aldehydes to provide the corresponding aldol products (e.g., 92) in excellent yields and high enantioselectivities (Scheme 39).[‌43‌] Turnover numbers of up to 8800 can be achieved. Such numbers are rare in organocatalysis and unprecedented in the enantioselective Mukaiyama aldol reaction. This kind of catalyst is a powerful practical tool for activation of unactivated substrates such as simple aldehydes.

Meeeee 88 Meeeeeeeee Meeeeeeee Meeee Meeeeeee Meeeeeeee ee e Meeeee Meeeeeeeeeeee Meeeeeee[‌88‌]

Meeeeeeeeeee Meeeeeeee

(M)-Meeeee 8,8-Meeeeeee-8-(8-eeeeeeee)-8-(eeeeeeeeeeeeeee)eeeeeeeeee (88); Meeeeee Meeeeeeee:[‌88‌]

Me e 8-eeee eeee eeeeeeee eeee e eeeeee eeeeee eee e eeeeeeee eeeeeee eee eee eeeee eeeee Me8M (8.8M ee eeeee) eee eeeeeeeeeee-8-eeeeeeeeeeee (8.88eeee), eee eeee eeeeeeeeeeeee 88 ee e eeeee eeee ee eeeee Me8M (8.88eM, 8eee%) eee eeeee. Mee eeee eee eeeeee ee 88°M eeeeee 8,8-eeeeeeeeeeeeee eeeee eeeeee 88 (8.888eeee, 8.8 eeeee) eee eeeee ee eee eeeeeee. Me eeeee eeeeeeeeee eee eeeeeeee. Mee eeeeeeee eee eeeeeeee eeee eee. ee MeMMM8, eeeeeeeee eeee Me8M (8×8eM), eee eeeee (Me8MM8). Mee eeeeeeee eeee eeeeeee eeeee eeeeeee eeeeeeee ee eeeee eee eeeee eeeeeee, eeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeeee/MeMMe 88:8) ee eeeee eee eeeeeee ee e eeeeeeeee eeeee; eeeee: 88%; ee 88:8.

References


Cookie-Einstellungen