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2.13 Direct Aldol Reactions

DOI: 10.1055/sos-SD-202-00331

Yliniemelä-Sipari, S. M.; Pihko, P. M.Science of Synthesis: Stereoselective Synthesis, (20112621.

General Introduction

The direct aldol reaction refers to aldol-type processes where unmodified enolizable carbonyl compounds are used as the reaction components (Scheme 1). Typically, the component to be enolized in the process is called the aldol donor and the carbonyl electrophile is called the aldol acceptor. The key challenge in the direct aldol process lies in the selective activation of the aldol donors in the presence of potentially enolizable aldol acceptors. Perhaps not surprisingly, many direct aldol processes are most successful when non-enolizable acceptors, such as aromatic aldehydes, are used. However, there are also several examples of selective processes where potentially enolizable carbonyl acceptors are used for direct aldol reactions.

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