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3.7.1.1 The Classic Claisen Rearrangement

DOI: 10.1055/sos-SD-203-00213

Zeh, J.; Hiersemann, M.Science of Synthesis: Stereoselective Synthesis, (20113353.

The Claisen rearrangement usually requires high temperature or catalysis by a π- or σ-Lewis acid, and therefore may not be applicable to substrates with sensitive functional groups. The allyl vinyl ether can be generated with a defined configuration of either double bond in situ or in a separate step that precedes the rearrangement.

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