Science of Synthesis

Jautze, S.; Peters, R., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 443.

The Claisen rearrangement has found widespread application as one of the most fundamental reactions in synthetic organic chemistry.[‌1‌–‌3‌] However, the number of practically useful, metal-catalyzed methods for enantioselective rearrangement is still relatively small.[‌4‌] In the majority of cases a chiral Lewis acid is used in stoichiometric amounts or even in excess as a result of product inhibition. Moreover, the few catalytic methods described are limited to special substrate classes.

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Meeeeeeeeeee Meeeeeeee

α-Mee Meeeee ‌8‌; Meeeeee Meeeeeeee Meeee e Meeeeeee Meeeee Meeeeeee:[‌8‌]

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References