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3.17 Baeyer–Villiger Reactions

DOI: 10.1055/sos-SD-203-00464

Levinger, S.Science of Synthesis: Stereoselective Synthesis, (20113747.

General Introduction

The peroxide-mediated insertion of an oxygen atom into the bond between a carbonyl carbon atom and another carbon or hydrogen atom is known as the BaeyerVilliger reaction or BaeyerVilliger oxidation (Scheme 1). Although this definition includes the oxidation of aldehydes and α-oxo ketones to give carboxylic acids and acid anhydrides respectively, it is the transformation of acyclic ketones (and some aldehydes) into esters, and that of cyclic ketones into lactones, that constitutes the main field of application.

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