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1.1.3 Enamine Catalysis of Mannich Reactions

DOI: 10.1055/sos-SD-204-00021

Benohoud, M.; Hayashi, Y.Science of Synthesis: Asymmetric Organocatalysis, (2012173.

General Introduction

Asymmetric reactions catalyzed by amines involving enamine intermediates were developed after the discovery of the intermolecular proline-catalyzed aldol reaction in 2000.[‌1‌] In the same year its application was reported for the aza variant of the aldol reaction: the Mannich reaction.[‌2‌]

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References