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DOI: 10.1055/sos-SD-204-00021

Benohoud, M.; Hayashi, Y.Science of Synthesis: Asymmetric Organocatalysis, (2012175.

The first asymmetric Mannich reaction catalyzed by an amine concerned the direct reaction of a ketone, an aldehyde, and 4-methoxyaniline (p-anisidine) in the presence of 35mol% of (S)-proline in dimethyl sulfoxide. The good yields and excellent enantioselectivities obtained are the origin of the success of organocatalyst-mediated Mannich reactions.[‌2‌]