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Please login to access the full content or check if you have access via1.1.3.1 Mannich Reaction of N-Arylimines with Carbonyl Compounds
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DOI:
10.1055/sos-SD-204-00021
Benohoud, M.; Hayashi, Y., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 75.
The first asymmetric Mannich reaction catalyzed by an amine concerned the direct reaction of a ketone, an aldehyde, and 4-methoxyaniline (p-anisidine) in the presence of 35 mol% of (S)-proline in dimethyl sulfoxide. The good yields and excellent enantioselectivities obtained are the origin of the success of organocatalyst-mediated Mannich reactions.[2]
References
| [2] | Meee, M., M. Me. Meee. Mee., (8888) 888, 8888. |
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